Marlins vs. Phillies prediction: Why Philadelphia is favored to win Wednesday's MLB matchup [9/24/2025]

The Philadelphia Phillies and Miami Marlins will meet in MLB action at Citizens Bank Park on Wednesday, starting at 6:45PM ET.

The Phillies will send Jesús Luzardo (14-7, 4.08 ERA) to the mound, while the Marlins have opted for Ryan Weathers (2-1, 3.21 ERA).

Based on updated simulations, Dimers' advanced MLB model projects the Phillies as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Marlins-Phillies game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Phillies' chance of winning at 63%, with the Marlins at 37%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Marlins vs. Phillies predictions page.

Phillies vs. Marlins prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Marlins and Phillies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Phillies a 63% chance of defeating the Marlins.

According to our model, the Marlins (+1.5) have a 57% chance of covering the run line, while the over/under total of 7.5 runs has a 57% chance of going over.

Marlins vs. Phillies odds [9/24/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Marlins	Phillies
Run Line	+1.5 (-155)	-1.5 (+138)
Moneyline	+140	-156
Total	o7.5 (-110)	u7.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Marlins vs. Phillies picks and best bets

Our model's biggest edge in today's Marlins vs. Phillies matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Marlins vs. Phillies game-day updates and essential details

Wednesday's MLB matchup between the Phillies and Marlins at Citizens Bank Park is scheduled to begin at 6:45PM ET.

• Who: Miami Marlins vs. Philadelphia Phillies
• Date: Wednesday, September 24, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Citizens Bank Park

Dimers' full preview of Wednesday's Marlins vs. Phillies matchup includes our prediction, picks and the latest betting odds.

Before making any Marlins vs. Phillies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Phillies, with a 63% win probability, will likely beat the Marlins on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Marlins vs. Phillies insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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