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Marlins vs. Cubs Prediction: Cubs Predicted to Win Monday's MLB Matchup [5/12/2025]

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Written by Dave Garofolo

Our expert prediction for Monday's Miami Marlins vs Chicago Cubs matchup.

Miami Marlins-Chicago Cubs Predictions and Game Preview.
Wrigley Field sets the stage for the MLB matchup between the Miami Marlins and Chicago Cubs this Monday.

The Chicago Cubs will take on the Miami Marlins in MLB action at Wrigley Field on Monday, commencing at 7:40PM ET.

The Cubs will have Colin Rea (2-0, 2.43 ERA) as their starting pitcher, up against Cal Quantrill (2-3, 7.10 ERA) for the Marlins.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Miami-CHI Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Cubs are likely to win, with a probability of 67%, compared to the Marlins' 33%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Marlins vs. Cubs predictions page.

Cubs vs. Marlins Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Monday's MLB matchup between the Marlins and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 67% chance of defeating the Marlins.

According to our model, the Marlins (+1.5) have a 52% chance of covering the run line, while the over/under total of 8 runs has a 53% chance of going over.

 

Marlins vs. Cubs Odds [5/12/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type Marlins Cubs
Run Line +1.5 (+105) -1.5 (-120)
Moneyline +220 -250
Total o8 (-112) u8 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Marlins vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Marlins vs. Cubs matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Marlins vs. Cubs Game-Day Updates and Essential Details

Monday's MLB game between the Cubs and Marlins at Wrigley Field is scheduled to commence at 7:40PM ET.

Dimers.com's in-depth preview of Monday's Marlins vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Miami vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

Conclusion

We predict the Cubs, with a 67% win probability, will likely beat the Marlins on Monday.

AI and automation have enhanced this article to quickly deliver accurate Marlins vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest probabilities for the World Series, American League, National League and each division.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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