Miami Dolphins vs. Indianapolis Colts updated prediction featuring De'Von Achane, Jonathan Taylor [Week 1, 2025]

Dimers' latest NFL predictions are live for Indianapolis Colts and Miami Dolphins in Week 1, with our model giving the Colts a 55% of winning against the Dolphins on Sunday.

This update builds on our early Colts-Dolphins predictions, delivering refreshed win probabilities, score projections, and TD predictions for De'Von Achane, Jonathan Taylor, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Dolphins vs. Colts page.

What's changed? Miami vs. Indianapolis updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Dolphins vs. Colts matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Dolphins 45%, Colts 55%
• Predicted Final Score: Dolphins 22-23 Colts
• Spread: Dolphins (+1.5) 50%, Colts (-1.5) 50%
• Total Points (46.5): Over 50%, Under 50%

As of September 5, 2025, these Dolphins-Colts calculations reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Dolphins-Colts on Sunday:

Miami Dolphins

• De'Von Achane: 55.3% probability
• Tyreek Hill: 38.0% probability
• Ollie Gordon: 30.5% probability

Indianapolis Colts

• Jonathan Taylor: 56.1% probability
• Michael Pittman: 25.1% probability
• Josh Downs: 24.7% probability

Dolphins vs. Colts latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Dolphins +1.5 (-118), Colts -1.5 (-102)
• Moneyline: Dolphins -108, Colts -108
• Total: Over/Under 46.5 (-115/-105)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Dolphins vs. Colts Week 1 details

The NFL Week 1 action between the Colts and Dolphins at Lucas Oil Stadium is scheduled for September 7, 2025.

• Who: Miami Dolphins vs. Indianapolis Colts
• Date: Sunday, September 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Lucas Oil Stadium

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Conclusion

We predict the Colts, with a 55% win probability, will likely beat the Dolphins in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Dolphins vs. Colts matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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