Miami Dolphins vs. Indianapolis Colts early prediction: Expert picks for NFL Week 1, 2025

The Miami Dolphins and Indianapolis Colts will meet in Week 1 of the NFL season at Lucas Oil Stadium on Sunday, September 7, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Colts as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Dolphins vs. Colts predictions page.

Miami vs. Indianapolis early predictions

Leveraging trusted machine learning and analysis, we have simulated the Dolphins vs. Colts game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Dolphins 45%, Colts 55%
• Predicted final score: Dolphins 22-23 Colts
• Spread: Dolphins (+1.5) 50%, Colts (-1.5) 50%
• Total points (46.5): Over 50%, Under 50%

As of August 31, 2025, these Dolphins-Colts numbers and predictions reflect the latest data and insights available.

Dolphins vs. Colts Week 1 details

The NFL Week 1 action between the Colts and Dolphins at Lucas Oil Stadium is scheduled for September 7, 2025.

• Who: Miami Dolphins vs. Indianapolis Colts
• Date: Sunday, September 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Lucas Oil Stadium

Dolphins vs. Colts opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: Dolphins +1.5 (-108), Colts -1.5 (-110)
• Moneyline: Dolphins +102, Colts -120
• Total: Over/Under 46.5 (-118/-102)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Colts, with a 55% win probability, will likely beat the Dolphins in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Dolphins vs. Colts matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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