Miami Dolphins vs. Carolina Panthers early prediction: Expert picks for NFL Week 5, 2025

The Miami Dolphins and Carolina Panthers will meet in Week 5 of the NFL season at Bank of America Stadium on Sunday, October 5, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Dolphins as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Dolphins vs. Panthers predictions page.

Miami vs. Carolina early predictions

Leveraging trusted machine learning and analysis, we have simulated the Dolphins vs. Panthers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Dolphins 59%, Panthers 41%
• Predicted final score: Dolphins 23-21 Panthers
• Spread: Dolphins (-1.5) 53%, Panthers (+1.5) 47%
• Total points (46.5): Over 47%, Under 53%

As of September 28, 2025, these Dolphins-Panthers numbers and predictions reflect the latest data and insights available.

Dolphins vs. Panthers Week 5 details

The NFL Week 5 game between the Panthers and Dolphins at Bank of America Stadium is scheduled for October 5, 2025.

• Who: Miami Dolphins vs. Carolina Panthers
• Date: Sunday, October 5, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Bank of America Stadium

Dolphins vs. Panthers opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: Dolphins -1.5 (-108), Panthers +1.5 (-112)
• Moneyline: Dolphins -125, Panthers +105
• Total: Over/Under 46.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Dolphins, with a 59% win probability, will likely beat the Panthers in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Dolphins vs. Panthers matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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