Dolphins vs. Bills prediction: Buffalo favored to win TNF Week 3, 2025

The Buffalo Bills will face the Miami Dolphins in NFL Week 3 action at Highmark Stadium on Thursday, starting at 8:15PM ET.

Based on updated simulation results, Dimers' advanced NFL model predicts the Bills as the most likely winner of today's game.

This gameday Dolphins vs. Bills betting preview builds on my early Dolphins vs. Bills prediction that was published earlier in the week.

For further insights into today’s game, including the predicted score, best bets and player prop picks, visit our interactive Dolphins vs. Bills predictions page.

Dolphins vs. Bills Predictions

Since our Dolphins-Bills predictions earlier in the week, we have simulated the result of Thursday's NFL game between the Dolphins and Bills 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the Bills an 83% chance of defeating the Dolphins in Week 3 of the NFL season. Our predicted final score has the Bills winning 30-19.

According to our model, the Dolphins (+12.5) have a 52% chance of covering the spread, while the over/under total of 50.5 points has an equal 50-50 chance of hitting.

Dolphins vs. Bills odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Dolphins	Bills
Spread	+12.5 (-112)	-12.5 (-108)
Moneyline	+600	-700
Total	o50.5 (-110)	u50.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Dolphins vs. Bills picks and best bets

Our model's strongest edge in today's Dolphins vs. Bills matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Dolphins vs. Bills TD scorers

Who will score an anytime touchdown in Dolphins vs. Bills?

According to our model, Buffalo's James Cook is most likely to score the first TD in Dolphins vs. Bills.

Our projections give Cook a 14.1% chance of scoring the first TD at Highmark Stadium, while the Bills running back is a 58.8% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Miami Dolphins

Player	First TD Probability
De'Von Achane (RB)	11.2%
Tyreek Hill (WR)	6.5%
Jaylen Waddle (WR)	4.4%

Buffalo Bills

Player	First TD Probability
James Cook (RB)	14.1%
Josh Allen (QB)	12.2%
Keon Coleman (WR)	6.0%

Anytime touchdown scorer predictions

Miami Dolphins

Player	Anytime TD Probability
De'Von Achane (RB)	51.0%
Tyreek Hill (WR)	34.1%
Jaylen Waddle (WR)	24.7%

Buffalo Bills

Player	Anytime TD Probability
James Cook (RB)	58.8%
Josh Allen (QB)	53.7%
Keon Coleman (WR)	31.6%

Dolphins vs Bills player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Dolphins and Bills. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Dolphins-Bills page now to access every player prop projection.

Dolphins vs. Bills quarterbacks

Of the starting quarterbacks, the Dolphins' Tua Tagovailoa is projected to throw for more yards than the Bills' Josh Allen.

Dolphins rushing

De'Von Achane, Jaylen Wright and Ollie Gordon are projected to be the leading rushers for the Dolphins.

Player	Position
De'Von Achane	RB
Jaylen Wright	RB
Ollie Gordon	RB

Bills rushing

James Cook, Josh Allen and Ray Davis are expected to lead the Bills in rushing yards.

Player	Position
James Cook	RB
Josh Allen	QB
Ray Davis	RB

Dolphins receiving

Tyreek Hill, Jaylen Waddle, De'Von Achane, Malik Washington and Tanner Conner are projected to top the receiving yards for the Dolphins.

Player	Position
Tyreek Hill	WR
Jaylen Waddle	WR
De'Von Achane	RB
Malik Washington	WR
Tanner Conner	TE

Bills receiving

Keon Coleman, Khalil Shakir, Joshua Palmer, Dalton Kincaid and Dawson Knox are projected to lead the Bills in receiving yards.

Player	Position
Keon Coleman	WR
Khalil Shakir	WR
Joshua Palmer	WR
Dalton Kincaid	TE
Dawson Knox	TE

Dolphins vs. Bills game-day updates and essential details

The NFL Week 3 action between the Bills and Dolphins at Highmark Stadium is scheduled to begin at 8:15PM ET.

• Who: Miami Dolphins vs. Buffalo Bills
• Date: Thursday, September 18, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Highmark Stadium

Dimers' in-depth preview of this week's Dolphins vs. Bills matchup includes our prediction, picks and the latest betting odds.

Before making any Dolphins vs. Bills picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Bills, with an 83% win probability, will likely beat the Dolphins in Week 3 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Dolphins vs. Bills insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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