Miami Dolphins vs. Buffalo Bills early prediction: Expert picks for NFL Week 3, 2025

The Miami Dolphins and Buffalo Bills will meet in Week 3 of the NFL season at Highmark Stadium on Thursday, September 18, 2025, starting at 8:15PM ET.

Early simulations from Dimers' trusted NFL model favor the Bills as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Dolphins vs. Bills predictions page.

Miami vs. Buffalo early predictions

Leveraging trusted machine learning and analysis, we have simulated the Dolphins vs. Bills game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Dolphins 26%, Bills 74%
• Predicted final score: Dolphins 20-27 Bills
• Spread: Dolphins (+8.5) 52%, Bills (-8.5) 48%
• Total points (48.5): Over 50%, Under 50%

As of September 14, 2025, these Dolphins-Bills calculations and predictions reflect the latest data and insights available.

Dolphins vs. Bills Week 3 details

The NFL Week 3 game between the Bills and Dolphins at Highmark Stadium is scheduled for September 18, 2025.

• Who: Miami Dolphins vs. Buffalo Bills
• Date: Thursday, September 18, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Highmark Stadium

Dolphins vs. Bills opening odds

We've researched the best betting odds across America for this Week 3 game, which are listed here:

• Spread: Dolphins +8.5 (-110), Bills -8.5 (-110)
• Moneyline: Dolphins +310, Bills -395
• Total: Over/Under 48.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Bills, with a 74% win probability, will likely beat the Dolphins in Week 3 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Dolphins vs. Bills matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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