Mercer vs. East Tennessee State prediction: Why Mercer is favored to win in college football Week 5, 2025

East Tennessee State will square off with Mercer in Week 5 college football action at William B. Greene Jr. Stadium on Saturday, starting at 5:30PM ET.

Based on updated simulations, Dimers' proven college football model projects Mercer as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Mercer vs. East Tennessee State predictions page.

Mercer vs. East Tennessee State prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the result of Mercer vs. East Tennessee State 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Mercer a 51% chance of beating East Tennessee State. Our predicted final score has Mercer winning 25-24.

According to our model, East Tennessee State (+2.5) has a 54% chance of covering the spread, while the over/under total of 52.5 points has a 56% chance of going over.

Mercer vs. East Tennessee State odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Mercer	East Tennessee State
Spread	-2.5 (+100)	+2.5 (-110)
Moneyline	-114	+114
Total	o52.5 (-110)	u52.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Mercer vs. East Tennessee State picks and best bets

Our model's strongest edge in today's Mercer vs. East Tennessee State matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Mercer vs. East Tennessee State game-day updates and essential details

Saturday's college football action between East Tennessee State and Mercer at William B. Greene Jr. Stadium is scheduled to begin at 5:30PM ET.

• Who: Mercer vs. East Tennessee State
• Date: Saturday, September 27, 2025
• Time: 5:30PM ET/2:30PM PT
• Venue: William B. Greene Jr. Stadium

Dimers' full preview of Saturday's Mercer vs. East Tennessee State matchup includes our prediction, picks and the latest betting odds.

Before making any Mercer vs. East Tennessee State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Mercer, with a 51% win probability, will likely beat East Tennessee State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Mercer vs. East Tennessee State insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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