UMass vs. Missouri prediction: Why Missouri is favored to win in college football Week 5, 2025

Missouri and Massachusetts will meet in Week 5 college football action at Memorial Stadium/Faurot Field on Saturday, with kickoff at 7:30PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Missouri as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive UMass vs. Missouri predictions page.

UMass vs. Missouri prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the result of UMass vs. Missouri 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Missouri a 100% chance of defeating Massachusetts. Our predicted final score has Missouri winning 50-6.

According to our model, the bookies have got it right, and Massachusetts and Missouri each have a 50% chance of covering the spread, while the over/under total of 56.5 points also has an equal 50-50 chance of hitting.

UMass vs. Missouri odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	UMass	Missouri
Spread	+44.5 (-110)	-44.5 (-105)
Moneyline	+8000	-100000
Total	o56.5 (-115)	u56.5 (-105)

All odds are correct at the time of publication and are subject to change.

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UMass vs. Missouri picks and best bets

Our model's strongest edge in today's UMass vs. Missouri matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

UMass vs. Missouri game-day updates and essential details

Saturday's college football matchup between Missouri and UMass at Memorial Stadium/Faurot Field is scheduled to commence at 7:30PM ET.

• Who: Massachusetts vs. Missouri
• Date: Saturday, September 27, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Memorial Stadium/Faurot Field

Dimers' comprehensive preview of Saturday's UMass vs. Missouri matchup includes our prediction, picks and the latest betting odds.

Before making any UMass vs. Missouri picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Missouri, with a 100% win probability, will likely beat Massachusetts on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Massachusetts vs. Missouri insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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