Marshall vs. Louisiana-Lafayette prediction: Marshall favored to win in college football Week 5, 2025

Louisiana-Lafayette will take on Marshall in Week 5 college football action at Cajun Field at Our Lady of Lourdes Stadium on Saturday, commencing at 8:00PM ET.

Based on the latest simulations, Dimers' proven college football model predicts Marshall as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Marshall vs. Louisiana-Lafayette predictions page.

Marshall vs. Louisiana-Lafayette prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Marshall vs. Louisiana-Lafayette 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Marshall a 51% chance of beating Louisiana-Lafayette. Our predicted score is Marshall 24-24 Louisiana-Lafayette.

According to our model, Louisiana-Lafayette (+1.5) has a 53% chance of covering the spread, while the 47.5-point over/under has a 53% chance of staying under.

While there is no way for a College Football game to end in a tie, our prediction of 24-24 is based on each team's average score in the above-mentioned simulations of Marshall vs. Louisiana-Lafayette.

Marshall vs. Louisiana-Lafayette odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Marshall	Louisiana-Lafayette
Spread	-1.5 (-125)	+1.5 (-105)
Moneyline	-125	+105
Total	o47.5 (-125)	u47.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Marshall vs. Louisiana-Lafayette picks and best bets

Our model's strongest edge in today's Marshall vs. Louisiana-Lafayette matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Marshall vs. Louisiana-Lafayette game-day updates and essential details

Saturday's college football matchup between Louisiana-Lafayette and Marshall at Cajun Field at Our Lady of Lourdes Stadium is scheduled to commence at 8:00PM ET.

• Who: Marshall vs. Louisiana-Lafayette
• Date: Saturday, September 27, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Cajun Field at Our Lady of Lourdes Stadium

Dimers' full preview of Saturday's Marshall vs. Louisiana-Lafayette matchup includes our prediction, picks and the latest betting odds.

Before making any Marshall vs. Louisiana-Lafayette picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Marshall, with a 51% win probability, will likely beat Louisiana-Lafayette on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Marshall vs. Louisiana-Lafayette insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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