LSU vs. Ole Miss prediction: Why Mississippi is favored to win in college football Week 5, 2025

Mississippi will face LSU in Week 5 college football action at Vaught-Hemingway Stadium on Saturday, with kickoff at 3:30PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts Mississippi as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive LSU vs. Ole Miss predictions page.

LSU vs. Ole Miss prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of LSU vs. Ole Miss 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Mississippi a 62% chance of defeating LSU. Our predicted final score has Mississippi winning 30-25.

According to our model, Mississippi (+1.5) has a 62% chance of covering the spread, while the 55.5-point over/under has a 55% chance of going over.

LSU vs. Ole Miss odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	LSU	Ole Miss
Spread	-1.5 (-118)	+1.5 (-112)
Moneyline	+115	-102
Total	o55.5 (-115)	u55.5 (-115)

All odds are correct at the time of publication and are subject to change.

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LSU vs. Ole Miss picks and best bets

Our model's strongest edge in today's LSU vs. Ole Miss matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

LSU vs. Ole Miss game-day updates and essential details

Saturday's college football action between Ole Miss and LSU at Vaught-Hemingway Stadium is scheduled to commence at 3:30PM ET.

• Who: LSU vs. Mississippi
• Date: Saturday, September 27, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Vaught-Hemingway Stadium

Dimers' full preview of Saturday's LSU vs. Ole Miss matchup includes our prediction, picks and the latest betting odds.

Before making any LSU vs. Ole Miss picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Mississippi, with a 62% win probability, will likely beat LSU on Saturday.

AI and automation have enhanced this article to quickly deliver accurate LSU vs. Mississippi insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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