LSU vs. Clemson prediction: Why Clemson is favored to win in college football Week 1, 2025

Clemson and LSU will meet in college football action at Memorial Stadium on Saturday, with kickoff at 7:30PM ET.

Based on updated simulation results, Dimers' proven college football model projects Clemson as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive LSU vs. Clemson predictions page.

LSU vs. Clemson prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the outcome of LSU vs. Clemson 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Clemson a 58% chance of beating LSU. Our predicted final score has Clemson winning 29-26.

According to our model, LSU (+5.5) has a 55% chance of covering the spread, while the 55.5-point over/under has a 52% chance of going over.

LSU vs. Clemson odds

We have sourced the best College Football odds in America for this game, which are listed here:

Bet Type	LSU	Clemson
Spread	+5.5 (-110)	-5.5 (-105)
Moneyline	+170	-196
Total	o55.5 (-108)	u55.5 (-110)

All odds are correct at the time of publication and are subject to change.

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LSU vs. Clemson picks and best bets

Our model's biggest edge in today's LSU vs. Clemson matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

LSU vs. Clemson game-day updates and essential details

Saturday's college football action between Clemson and LSU at Memorial Stadium is scheduled to start at 7:30PM ET.

• Who: LSU vs. Clemson
• Date: Saturday, August 30, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Memorial Stadium

Dimers.com's full preview of Saturday's LSU vs. Clemson matchup includes our prediction, picks and the latest betting odds.

Before making any LSU vs. Clemson picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Clemson, with a 58% win probability, will likely beat LSU on Saturday.

AI and automation have enhanced this article to quickly deliver accurate LSU vs. Clemson insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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