Louisville vs. Pittsburgh prediction: Why Louisville is favored to win in college football Week 5, 2025

Pittsburgh and Louisville will clash in Week 5 college football action at Acrisure Stadium on Saturday, starting at 12:00PM ET.

Based on the latest simulation results, Dimers' proven college football model projects Louisville as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Louisville vs. Pittsburgh predictions page.

Louisville vs. Pittsburgh prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Louisville vs. Pittsburgh 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Louisville a 54% chance of beating Pittsburgh. Our predicted final score has Louisville winning 27-26.

According to our model, Pittsburgh (+3) has a 55% chance of covering the spread, while the over/under total of 54.5 points has a 54% chance of going over.

Louisville vs. Pittsburgh odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Louisville	Pittsburgh
Spread	-3 (-105)	+3 (-115)
Moneyline	-118	+125
Total	o54.5 (-105)	u54.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Louisville vs. Pittsburgh picks and best bets

Our model's biggest edge in today's Louisville vs. Pittsburgh matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Louisville vs. Pittsburgh game-day updates and essential details

Saturday's college football matchup between Pittsburgh and Louisville at Acrisure Stadium is scheduled to commence at 12:00PM ET.

• Who: Louisville vs. Pittsburgh
• Date: Saturday, September 27, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Acrisure Stadium

Dimers' full preview of Saturday's Louisville vs. Pittsburgh matchup includes our prediction, picks and the latest betting odds.

Before making any Louisville vs. Pittsburgh picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Louisville, with a 54% win probability, will likely beat Pittsburgh on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Louisville vs. Pittsburgh insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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