Louisiana-Lafayette vs. Missouri prediction: Why Missouri is favored to win in college football Week 3, 2025

Missouri will square off with Louisiana-Lafayette in Week 3 college football action at Memorial Stadium/Faurot Field on Saturday, starting at 1:00PM ET.

Based on the latest simulations, Dimers' advanced college football model projects Missouri as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Louisiana-Lafayette vs. Missouri predictions page.

Louisiana-Lafayette vs. Missouri prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Louisiana-Lafayette vs. Missouri 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Missouri a 97% chance of beating Louisiana-Lafayette. Our predicted final score has Missouri winning 37-10.

According to our model, Louisiana-Lafayette (+27.5) has a 52% chance of covering the spread, while the 47.5-point over/under has an equal 50-50 chance of hitting.

Louisiana-Lafayette vs. Missouri odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Louisiana-Lafayette	Missouri
Spread	+27.5 (-115)	-27.5 (-105)
Moneyline	+2000	-10000
Total	o47.5 (-110)	u47.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Louisiana-Lafayette vs. Missouri picks and best bets

Our model's strongest edge in today's Louisiana-Lafayette vs. Missouri matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Louisiana-Lafayette vs. Missouri game-day updates and essential details

Saturday's college football matchup between Missouri and Louisiana-Lafayette at Memorial Stadium/Faurot Field is scheduled to commence at 1:00PM ET.

• Who: Louisiana-Lafayette vs. Missouri
• Date: Saturday, September 13, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Memorial Stadium/Faurot Field

Dimers' in-depth preview of Saturday's Louisiana-Lafayette vs. Missouri matchup includes our prediction, picks and the latest betting odds.

Before making any Louisiana-Lafayette vs. Missouri picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Missouri, with a 97% win probability, will likely beat Louisiana-Lafayette on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Louisiana-Lafayette vs. Missouri insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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