Los Angeles Rams vs. Tennessee Titans early prediction: Expert picks for NFL Week 2, 2025

The Los Angeles Rams and Tennessee Titans will meet in Week 2 of the NFL season at Nissan Stadium on Sunday, September 14, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Rams as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Rams vs. Titans predictions page.

LA Rams vs. Tennessee early predictions

Leveraging trusted machine learning and analysis, we have simulated the Rams vs. Titans game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Rams 68%, Titans 32%
• Predicted final score: Rams 24-20 Titans
• Spread: Rams (-5.5) 46%, Titans (+5.5) 54%
• Total points (45.5): Over 45%, Under 55%

As of September 7, 2025, these Rams-Titans numbers and predictions reflect the latest data and insights available.

Rams vs. Titans Week 2 details

The NFL Week 2 game between the Titans and Rams at Nissan Stadium is scheduled for September 14, 2025.

• Who: Los Angeles Rams vs. Tennessee Titans
• Date: Sunday, September 14, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Nissan Stadium

Rams vs. Titans opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Rams -5.5 (-110), Titans +5.5 (-110)
• Moneyline: Rams -245, Titans +200
• Total: Over/Under 45.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Rams, with a 68% win probability, will likely beat the Titans in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Rams vs. Titans matchup, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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