Los Angeles Rams vs. Philadelphia Eagles early prediction: Expert picks for NFL Week 3, 2025

The Los Angeles Rams and Philadelphia Eagles will meet in Week 3 of the NFL season at Lincoln Financial Field on Sunday, September 21, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Eagles as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Rams vs. Eagles predictions page.

LA Rams vs. Philadelphia early predictions

Leveraging trusted machine learning and analysis, we have simulated the Rams vs. Eagles game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Rams 35%, Eagles 65%
• Predicted final score: Rams 20-24 Eagles
• Spread: Rams (+4.5) 54%, Eagles (-4.5) 46%
• Total points (46.5): Over 47%, Under 53%

As of September 14, 2025, these Rams-Eagles figures and predictions reflect the latest data and insights available.

Rams vs. Eagles Week 3 details

The NFL Week 3 game between the Eagles and Rams at Lincoln Financial Field is scheduled for September 21, 2025.

• Who: Los Angeles Rams vs. Philadelphia Eagles
• Date: Sunday, September 21, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Lincoln Financial Field

Rams vs. Eagles opening odds

We've researched the best betting odds across America for this Week 3 game, which are listed here:

• Spread: Rams +4.5 (-105), Eagles -4.5 (-115)
• Moneyline: Rams +180, Eagles -218
• Total: Over/Under 46.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Eagles, with a 65% win probability, will likely beat the Rams in Week 3 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Rams vs. Eagles matchup, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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