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Los Angeles Rams vs. Indianapolis Colts NFL Betting Picks, Predictions and Props: Sunday September 19, 2021

Matthew Stafford and his Los Angeles Rams head to Lucas Oil Stadium this Sunday to take on the Indianapolis Colts and it looks like a fun matchup for fans and bettors alike.
The 2021 NFL continues on Sunday September 19, 2021, and, as always, Dimers.com has simulated Rams vs. Colts 10,000 times to determine where the value lies for football bettors across the United States.
With NFL betting picks, probabilities, odds and predicted scores featured each and every week at Dimers, check out our top plays for this NFL 2021 Week 2 matchup.
Today's NFL best bets and odds are proudly brought to you by TwinSpires Sportsbook.
NFL 2021 Week 2: Rams vs. Colts
💰 Best Bet
The Rams were impressive last week against the Bears, on both the offensive and defensive sides of the field. Whilst we expect them to win again this week, there's not enough value there so we're instead tackling the total points.
The Rams defense is looking like it will be one of the strongest in the league again this season and they should have no trouble keeping the Colts to a low score, with the Under following suit.
You can see all live probabilities in the interactive widget below. Remember, our predictive analytics model is constantly simulating every NFL matchup to find the best value on the spread, moneyline, over/under and player props!
PICK: Total points UNDER 48 (-110) @ TwinSpires
🔥 Best Player Prop
Matthew Stafford means business. Now, there's no guarantee that he will star all the way through to January but he's got some great receivers and should be able to clock up around 300 yards again as he did in Week 1.
PICK: Matthew Stafford OVER 277.5 passing yards (-114) @ TwinSpires
MORE: DimersBOT's most likely TD scorers
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🎁 Best Sportsbook Promo
Both of these teams could threaten to win the Super Bowl this season, with the Rams in particular, taking DimersBOT's fancy, sitting as the sixth most likely champion.
If you place a $50 bet on any team to win the Super Bowl with Twinspires Sportsbook, you'll score yourself $10 every time they win this season. Yep, even if they don't win the big one, you'll be in the black as soon as your chosen team wins its fifth game of the season!
CLAIM: TwinSpires Super Bowl promotion
If you're looking for some inspiration, you can check out the Super Bowl probabilities for every team in the NFL.
MORE: Rams vs. Colts picks and predictions
NFL 2021 Week 2 Schedule
Thursday September 16, 2021
Sunday September 19, 2021
- Denver Broncos at Jacksonville Jaguars, 1PM ET
- Buffalo Bills at Miami Dolphins, 1PM ET
- Houston Texans at Cleveland Browns, 1PM ET
- Cincinnati Bengals at Chicago Bears, 1PM ET
- San Francisco 49ers at Philadelphia Eagles, 1PM ET
- New Orleans Saints at Carolina Panthers, 1PM ET
- Los Angeles Rams at Indianapolis Colts, 1PM ET
- Las Vegas Raiders at Pittsburgh Steelers, 1PM ET
- New England Patriots at New York Jets, 1PM ET
- Minnesota Vikings at Arizona Cardinals, 4:05PM ET
- Atlanta Falcons at Tampa Bay Buccaneers, 4:05PM ET
- Dallas Cowboys at Los Angeles Chargers, 4:25PM ET
- Tennessee Titans at Seattle Seahawks, 4:25PM ET
- Kansas City Chiefs at Baltimore Ravens, 8:20PM ET (Sunday Night Football)
Monday September 20, 2021
We've sourced and reviewed the Best 2021 NFL Sportsbook Promotions so you don't have to! Click in to see what the 'books are serving up!