Dodgers vs. Cardinals Prediction: St. Louis Predicted to Win Friday's MLB Matchup [6/6/2025]

The St. Louis Cardinals will take on the Los Angeles Dodgers in MLB action at Busch Stadium on Friday, beginning at 8:15PM ET.

The Cardinals will start Sonny Gray (6-1, 3.65 ERA), up against Justin Wrobleski (1-1, 8.00 ERA) for the Dodgers.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's LA Dodgers-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Cardinals' chance of winning is 52%, while the Dodgers' is 48%."

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Dodgers vs. Cardinals predictions page.

Cardinals vs. Dodgers Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Friday's MLB game between the Dodgers and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cardinals a 52% chance of defeating the Dodgers.

According to our model, the Dodgers (+1.5) have a 65% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of going over.

Dodgers vs. Cardinals Odds [6/6/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Dodgers	Cardinals
Run Line	+1.5 (-220)	-1.5 (+165)
Moneyline	+100	-112
Total	o8.5 (-118)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Dodgers vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Dodgers vs. Cardinals matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Dodgers vs. Cardinals Game-Day Updates and Essential Details

Friday's MLB game between the Cardinals and Dodgers at Busch Stadium is scheduled to start at 8:15PM ET.

• Who: Los Angeles Dodgers vs. St. Louis Cardinals
• Date: Friday, June 6, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Friday's Dodgers vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any LA Dodgers vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cardinals, with a 52% win probability, will likely beat the Dodgers on Friday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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