Dodgers vs. Mariners prediction: Seattle favored to win Friday's MLB matchup [9/26/2025]

The Seattle Mariners will take on the Los Angeles Dodgers in MLB action at T-Mobile Park on Friday, starting at 9:40PM ET.

The Mariners will start George Kirby (10-7, 4.24 ERA), while the Dodgers have opted for Emmet Sheehan (6-3, 2.86 ERA).

Based on the latest simulation results, Dimers' proven MLB model projects the Mariners as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Dodgers vs. Mariners predictions page.

Mariners vs. Dodgers prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the outcome of Friday's MLB game between the Dodgers and Mariners 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Mariners a 56% chance of beating the Dodgers.

According to our model, the Dodgers (+1.5) have a 63% chance of covering the run line, while the over/under total of 7 runs has a 61% chance of going over.

Dodgers vs. Mariners odds [9/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Dodgers	Mariners
Run Line	+1.5 (-180)	-1.5 (+152)
Moneyline	+126	-148
Total	o7 (-101)	u7 (-114)

All odds are correct at the time of publication and are subject to change.

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Dodgers vs. Mariners picks and best bets

Our model's strongest edge in today's Dodgers vs. Mariners matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Dodgers vs. Mariners game-day updates and essential details

Friday's MLB game between the Mariners and Dodgers at T-Mobile Park is scheduled to commence at 9:40PM ET.

• Who: Los Angeles Dodgers vs. Seattle Mariners
• Date: Friday, September 26, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: T-Mobile Park

Dimers' comprehensive preview of Friday's Dodgers vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Dodgers vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Mariners, with a 56% win probability, will likely beat the Dodgers on Friday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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