Dodgers vs. Giants prediction: Cy Young candidate Yoshinobu Yamamoto takes on Giants tonight [9/12/2025]

The San Francisco Giants will face the Los Angeles Dodgers in MLB action at Oracle Park on Friday, commencing at 10:15PM ET.

Justin Verlander (3-10, 4.09 ERA) will be the starting pitcher for the Giants, pitting him against Cy Young hopeful Yoshinobu Yamamoto (11-8, 2.72 ERA) for the Dodgers.

Based on updated simulation results, Dimers' advanced MLB model predicts the Dodgers as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Dodgers vs. Giants predictions page.

Giants vs. Dodgers prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's MLB matchup between the Dodgers and Giants 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Dodgers a 58% chance of defeating the Giants.

According to our model, the Giants (+1.5) have a 55% chance of covering the run line, while the over/under total of 7.5 runs has a 54% chance of going over.

Dodgers vs. Giants odds [9/12/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Dodgers	Giants
Run Line	-1.5 (+115)	+1.5 (-135)
Moneyline	-150	+134
Total	o7.5 (-105)	u7.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Dodgers vs. Giants picks and best bets

Our model's strongest edge in today's Dodgers vs. Giants matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Dodgers vs. Giants game-day updates and essential details

Friday's MLB action between the Giants and Dodgers at Oracle Park is scheduled to commence at 10:15PM ET.

• Who: Los Angeles Dodgers vs. San Francisco Giants
• Date: Friday, September 12, 2025
• Time: 10:15PM ET/7:15PM PT
• Venue: Oracle Park

Dimers' comprehensive preview of Friday's Dodgers vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Dodgers vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Dodgers, with a 58% win probability, will likely beat the Giants on Friday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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