Dodgers vs. Padres prediction: Dodgers favored to win Saturday's MLB matchup [8/23/2025]

The San Diego Padres will face the Los Angeles Dodgers, in what is expected to be a tight MLB game, at PETCO Park on Saturday, commencing at 8:40PM ET.

The Padres will start Nestor Cortes (1-2, 5.87 ERA), up against Tyler Glasnow (1-1, 3.12 ERA) for the Dodgers.

Based on the latest simulations, Dimers' advanced MLB model projects the Dodgers as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Dodgers vs. Padres predictions page.

Padres vs. Dodgers prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Saturday's MLB game between the Dodgers and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Dodgers a 54% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 60% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Dodgers vs. Padres odds [8/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Dodgers	Padres
Run Line	-1.5 (+125)	+1.5 (-140)
Moneyline	-136	+120
Total	o8.5 (-115)	u8.5 (-103)

All odds are correct at the time of publication and are subject to change.

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Dodgers vs. Padres picks and best bets

Our model's strongest edge in today's Dodgers vs. Padres matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Dodgers vs. Padres game-day updates and essential details

Saturday's MLB game between the Padres and Dodgers at PETCO Park is scheduled to begin at 8:40PM ET.

• Who: Los Angeles Dodgers vs. San Diego Padres
• Date: Saturday, August 23, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: PETCO Park

Dimers.com's full preview of Saturday's Dodgers vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Dodgers vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Dodgers, with a 54% win probability, will likely beat the Padres on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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