Dodgers vs. Padres prediction: Dodgers favored to win Friday's MLB matchup [8/22/2025]

The San Diego Padres will take on the Los Angeles Dodgers in MLB action at PETCO Park on Friday, starting at 9:40PM ET.

The Padres will send Yu Darvish (2-3, 5.97 ERA) to the mound, while the Dodgers are going with Blake Snell (3-1, 1.80 ERA).

Based on updated simulation results, Dimers' advanced MLB model predicts the Dodgers as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Dodgers vs. Padres predictions page.

Padres vs. Dodgers prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Friday's MLB game between the Dodgers and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Dodgers a 51% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 62% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of staying under.

Dodgers vs. Padres odds [8/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Dodgers	Padres
Run Line	-1.5 (+140)	+1.5 (-162)
Moneyline	-122	+105
Total	o8.5 (-102)	u8.5 (-116)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Dodgers vs. Padres picks and best bets

Our model's biggest edge in today's Dodgers vs. Padres matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Dodgers vs. Padres game-day updates and essential details

Friday's MLB action between the Padres and Dodgers at PETCO Park is scheduled to start at 9:40PM ET.

• Who: Los Angeles Dodgers vs. San Diego Padres
• Date: Friday, August 22, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's comprehensive preview of Friday's Dodgers vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Dodgers vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Sports betting deal available for Friday

To make the most of Friday's exciting day of sports, headlined by the TOUR Championship golf tournament and a huge day of MLB, check out details on the latest Bet365 bonus that unlocks $200 in bonus bets from a $5 bet. Don't miss out!

Conclusion

We predict the Dodgers, with a 51% win probability, will likely beat the Padres on Friday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest probabilities for the World Series, American League, National League and each division.