Dodgers vs. Guardians Prediction: Dodgers Predicted to Win Wednesday's MLB Matchup [5/28/2025]

The Cleveland Guardians will take on the Los Angeles Dodgers in MLB action at Progressive Field on Wednesday, beginning at 1:10PM ET.

The Guardians will start Kolby Allard (2-0, 1.50 ERA), up against Clayton Kershaw (0-0, 7.50 ERA) for the Dodgers.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Dodgers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's LA Dodgers-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Dodgers' chance of winning at 60%, with the Guardians at 40%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Dodgers vs. Guardians predictions page.

Guardians vs. Dodgers Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Dodgers and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Dodgers a 60% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 53% chance of covering the run line, while the 8.5-run over/under has a 54% chance of going over.

Dodgers vs. Guardians Odds [5/28/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Dodgers	Guardians
Run Line	-1.5 (+100)	+1.5 (-113)
Moneyline	-170	+146
Total	o8.5 (-114)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Dodgers vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Dodgers vs. Guardians matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Dodgers vs. Guardians Game-Day Updates and Essential Details

Wednesday's MLB game between the Guardians and Dodgers at Progressive Field is scheduled to start at 1:10PM ET.

• Who: Los Angeles Dodgers vs. Cleveland Guardians
• Date: Wednesday, May 28, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Wednesday's Dodgers vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any LA Dodgers vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Dodgers, with a 60% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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