Dodgers vs. Orioles prediction: Dodgers favored to win Friday's MLB matchup [9/5/2025]

The Baltimore Orioles and Los Angeles Dodgers will lock horns in MLB action at Oriole Park at Camden Yards on Friday, starting at 7:05PM ET.

Dean Kremer (9-10, 4.52 ERA) will get the ball for the Orioles, pitting him against Shohei Ohtani (1-1, 4.18 ERA) for the Dodgers.

Based on the latest simulation results, Dimers' proven MLB model projects the Dodgers as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Dodgers vs. Orioles predictions page.

Orioles vs. Dodgers prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Friday's MLB matchup between the Dodgers and Orioles 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Dodgers a 61% chance of defeating the Orioles.

According to our model, the Orioles (+1.5) have a 52% chance of covering the run line, while the 9-run over/under has a 53% chance of going over.

Dodgers vs. Orioles odds [9/5/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Dodgers	Orioles
Run Line	-1.5 (-102)	+1.5 (-115)
Moneyline	-164	+140
Total	o9 (-105)	u9 (-110)

All odds are correct at the time of publication and are subject to change.

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Dodgers vs. Orioles picks and best bets

Our model's biggest edge in today's Dodgers vs. Orioles matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Dodgers vs. Orioles game-day updates and essential details

Friday's MLB game between the Orioles and Dodgers at Oriole Park at Camden Yards is scheduled to commence at 7:05PM ET.

• Who: Los Angeles Dodgers vs. Baltimore Orioles
• Date: Friday, September 5, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: Oriole Park at Camden Yards

Dimers.com's in-depth preview of Friday's Dodgers vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Dodgers vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Dodgers, with a 61% win probability, will likely beat the Orioles on Friday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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