Dodgers vs. Diamondbacks prediction: Why Dodgers are favored to win Wednesday's MLB matchup [9/24/2025]

The Arizona Diamondbacks and Los Angeles Dodgers are scheduled to meet in MLB action at Chase Field on Wednesday, starting at 9:40PM ET.

The Diamondbacks will send Ryne Nelson (7-3, 3.34 ERA) to the mound, pitting him against Blake Snell (5-4, 2.44 ERA) for the Dodgers.

Based on updated simulations, Dimers' proven MLB model predicts the Dodgers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Dodgers-Diamondbacks game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Dodgers' chance of winning at 59%, with the Diamondbacks at 41%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Dodgers vs. Diamondbacks predictions page.

Diamondbacks vs. Dodgers prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the result of Wednesday's MLB game between the Dodgers and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Dodgers a 59% chance of defeating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 55% chance of covering the run line, while the 8.5-run over/under has a 58% chance of going over.

Dodgers vs. Diamondbacks odds [9/24/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Dodgers	Diamondbacks
Run Line	-1.5 (+118)	+1.5 (-135)
Moneyline	-142	+125
Total	o8.5 (-108)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Dodgers vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Dodgers vs. Diamondbacks matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Dodgers vs. Diamondbacks game-day updates and essential details

Wednesday's MLB action between the Diamondbacks and Dodgers at Chase Field is scheduled to begin at 9:40PM ET.

• Who: Los Angeles Dodgers vs. Arizona Diamondbacks
• Date: Wednesday, September 24, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers' in-depth preview of Wednesday's Dodgers vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Dodgers vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Dodgers, with a 59% win probability, will likely beat the Diamondbacks on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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