Dodgers vs. Diamondbacks prediction: Why Dodgers are favored to win Tuesday's MLB matchup [9/23/2025]

The Arizona Diamondbacks will take on the Los Angeles Dodgers in MLB action at Chase Field on Tuesday, starting at 9:40PM ET.

Brandon Pfaadt (13-8, 5.02 ERA) will start on the mound for the Diamondbacks, while the Dodgers have opted for Shohei Ohtani (1-1, 3.29 ERA).

Based on the latest simulations, Dimers' advanced MLB model predicts the Dodgers as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Dodgers vs. Diamondbacks predictions page.

Diamondbacks vs. Dodgers prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Dodgers and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Dodgers a 60% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 52% chance of covering the run line, while the 9-run over/under has a 57% chance of going over.

Dodgers vs. Diamondbacks odds [9/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Dodgers	Diamondbacks
Run Line	-1.5 (-101)	+1.5 (-118)
Moneyline	-162	+140
Total	o9 (+104)	u9 (-109)

All odds are correct at the time of publication and are subject to change.

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Dodgers vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Dodgers vs. Diamondbacks matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Dodgers vs. Diamondbacks game-day updates and essential details

Tuesday's MLB matchup between the Diamondbacks and Dodgers at Chase Field is scheduled to commence at 9:40PM ET.

• Who: Los Angeles Dodgers vs. Arizona Diamondbacks
• Date: Tuesday, September 23, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers' in-depth preview of Tuesday's Dodgers vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Dodgers vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Dodgers, with a 60% win probability, will likely beat the Diamondbacks on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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