Los Angeles Chargers vs. New York Giants updated prediction featuring Omarion Hampton, Cam Skattebo [Week 4, 2025]

Dimers' latest NFL predictions are live for New York Giants and Los Angeles Chargers in Week 4, with our model giving the Chargers a 72% of winning against the Giants on Sunday.

This update builds on our early Giants-Chargers predictions, delivering renewed win probabilities, score projections, and TD predictions for Omarion Hampton, Cam Skattebo, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Chargers vs. Giants page.

What's changed? LA Chargers vs. NY Giants updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Chargers vs. Giants matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Chargers 72%, Giants 28%
• Predicted Final Score: Chargers 25-19 Giants
• Spread: Chargers (-6.5) 43%, Giants (+6.5) 57%
• Total Points (43.5): Over 56%, Under 44%

As of September 25, 2025, these Chargers-Giants calculations reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Chargers-Giants on Sunday:

Los Angeles Chargers

• Omarion Hampton: 54.5% probability
• Quentin Johnston: 32.9% probability
• Keenan Allen: 32.7% probability

New York Giants

• Cam Skattebo: 49.5% probability
• Malik Nabers: 33.4% probability
• Wan'Dale Robinson: 23.8% probability

Chargers vs. Giants latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Chargers -6.5 (-105), Giants +6.5 (-110)
• Moneyline: Chargers -275, Giants +240
• Total: Over/Under 43.5 (-110/-105)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Chargers vs. Giants Week 4 details

The NFL Week 4 matchup between the Giants and Chargers at MetLife Stadium is scheduled for September 28, 2025.

• Who: Los Angeles Chargers vs. New York Giants
• Date: Sunday, September 28, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: MetLife Stadium

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Conclusion

We predict the Chargers, with a 72% win probability, will likely beat the Giants in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Chargers vs. Giants game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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