Chargers vs. Giants prediction: Chargers favored to win in NFL Week 4, 2025

The New York Giants will take on the favored Los Angeles Chargers in NFL Week 4 action at MetLife Stadium on Sunday, starting at 1:00PM ET.

Based on the latest simulation results, Dimers' advanced NFL model predicts the Chargers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Chargers-Giants game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Chargers with a win probability of 72%, while the Giants have 28%."

This gameday Chargers vs. Giants betting preview builds on my Chargers vs. Giants prediction that was published earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Chargers vs. Giants predictions page.

Chargers vs. Giants Predictions

Since our Chargers-Giants predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Chargers and Giants 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the Chargers a 72% chance of defeating the Giants in Week 4 of the NFL season. Our predicted final score has the Chargers winning 24-18.

According to our model, the Chargers (-6) have a 54% chance of covering the spread, while the over/under total of 42 points has a 57% chance of going over.

Chargers vs. Giants odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Chargers	Giants
Spread	-6 (-110)	+6 (-108)
Moneyline	-275	+230
Total	o42 (-118)	u42 (-110)

All odds are correct at the time of publication and are subject to change.

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Chargers vs. Giants picks and best bets

Our model's strongest edge in today's Chargers vs. Giants matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Chargers vs. Giants TD scorers

Who will score the first touchdown in Chargers vs. Giants?

According to our model, Los Angeles' Omarion Hampton is most likely to score the first TD in Chargers vs. Giants.

Our projections give Hampton a 15.5% chance of getting in for six first at MetLife Stadium, while the Chargers running back is a 53.3% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Los Angeles Chargers

Player	First TD Probability
Omarion Hampton (RB)	15.5%
Quentin Johnston (WR)	8.1%
Keenan Allen (WR)	7.8%

New York Giants

Player	First TD Probability
Cam Skattebo (RB)	11.6%
Malik Nabers (WR)	7.6%
Wan'Dale Robinson (WR)	4.4%

Anytime touchdown scorer predictions

Los Angeles Chargers

Player	Anytime TD Probability
Omarion Hampton (RB)	53.3%
Quentin Johnston (WR)	32.7%
Keenan Allen (WR)	31.6%

New York Giants

Player	Anytime TD Probability
Cam Skattebo (RB)	46.4%
Malik Nabers (WR)	33.5%
Wan'Dale Robinson (WR)	21.2%

Chargers vs Giants player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Chargers and Giants. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Chargers-Giants page now to access every player prop projection.

Chargers vs. Giants quarterbacks

Of the starting quarterbacks, the Chargers' Justin Herbert is projected to throw for more yards than the Giants' Jaxson Dart.

Chargers rushing

Omarion Hampton, Justin Herbert and Hassan Haskins are projected to be the leading rushers for the Chargers.

Player	Position
Omarion Hampton	RB
Justin Herbert	QB
Hassan Haskins	RB

Giants rushing

Cam Skattebo, Jaxson Dart and Devin Singletary are expected to lead the Giants in rushing yards.

Player	Position
Cam Skattebo	RB
Jaxson Dart	QB
Devin Singletary	RB

Chargers receiving

Ladd McConkey, Keenan Allen, Quentin Johnston, Oronde Gadsden and Omarion Hampton are projected to top the receiving yards for the Chargers.

Player	Position
Ladd McConkey	WR
Keenan Allen	WR
Quentin Johnston	WR
Oronde Gadsden	TE
Omarion Hampton	RB

Giants receiving

Malik Nabers, Wan'Dale Robinson, Darius Slayton, Cam Skattebo and Theo Johnson are projected to lead the Giants in receiving yards.

Player	Position
Malik Nabers	WR
Wan'Dale Robinson	WR
Darius Slayton	WR
Cam Skattebo	RB
Theo Johnson	TE

Chargers vs. Giants game-day updates and essential details

The NFL Week 4 action between the Giants and Chargers at MetLife Stadium is scheduled to commence at 1:00PM ET.

• Who: Los Angeles Chargers vs. New York Giants
• Date: Sunday, September 28, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: MetLife Stadium

Dimers' comprehensive preview of this week's Chargers vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Chargers vs. Giants picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Chargers, with a 72% win probability, will likely beat the Giants in Week 4 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Chargers vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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