Los Angeles Chargers vs. New York Giants early prediction: Expert picks for NFL Week 4, 2025

The Los Angeles Chargers and New York Giants will meet in Week 4 of the NFL season at MetLife Stadium on Sunday, September 28, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Chargers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Chargers vs. Giants predictions page.

LA Chargers vs. NY Giants early predictions

Leveraging trusted machine learning and analysis, we have simulated the Chargers vs. Giants game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Chargers 63%, Giants 37%
• Predicted final score: Chargers 23-19 Giants
• Spread: Chargers (-3.5) 50%, Giants (+3.5) 50%
• Total points (43.5): Over 50%, Under 50%

As of September 21, 2025, these Chargers-Giants calculations and predictions reflect the latest data and insights available.

Chargers vs. Giants Week 4 details

The NFL Week 4 game between the Giants and Chargers at MetLife Stadium is scheduled for September 28, 2025.

• Who: Los Angeles Chargers vs. New York Giants
• Date: Sunday, September 28, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: MetLife Stadium

Chargers vs. Giants opening odds

We've researched the best betting odds across America for this Week 4 game, which are listed here:

• Spread: Chargers -3.5 (-110), Giants +3.5 (-110)
• Moneyline: Chargers -185, Giants +154
• Total: Over/Under 43.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Chargers, with a 63% win probability, will likely beat the Giants in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Chargers vs. Giants matchup, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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