Los Angeles Chargers vs. Las Vegas Raiders early prediction: Expert picks for NFL Week 2, 2025

The Los Angeles Chargers and Las Vegas Raiders will meet in Week 2 of the NFL season at Allegiant Stadium on Monday, September 15, 2025, starting at 10:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Chargers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Chargers vs. Raiders predictions page.

LA Chargers vs. Las Vegas early predictions

Leveraging trusted machine learning and analysis, we have simulated the Chargers vs. Raiders game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Chargers 62%, Raiders 38%
• Predicted final score: Chargers 23-20 Raiders
• Spread: Chargers (-3) 50%, Raiders (+3) 50%
• Total points (44.5): Over 44%, Under 56%

As of September 7, 2025, these Chargers-Raiders figures and predictions reflect the latest data and insights available.

Chargers vs. Raiders Week 2 details

The NFL Week 2 action between the Raiders and Chargers at Allegiant Stadium is scheduled for September 15, 2025.

• Who: Los Angeles Chargers vs. Las Vegas Raiders
• Date: Monday, September 15, 2025
• Time: 10:00PM ET/7:00PM PT
• Venue: Allegiant Stadium

Chargers vs. Raiders opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Chargers -3 (-110), Raiders +3 (-110)
• Moneyline: Chargers -162, Raiders +136
• Total: Over/Under 44.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Chargers, with a 62% win probability, will likely beat the Raiders in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Chargers vs. Raiders game, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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