Angels vs. Mariners prediction: Seattle favored to win Friday's MLB matchup [9/12/2025]

The Seattle Mariners will square off with the Los Angeles Angels in MLB action at T-Mobile Park on Friday, starting at 10:10PM ET.

The Mariners will have Luis Castillo (9-8, 3.85 ERA) as their starting pitcher, while the Angels are going with Yusei Kikuchi (6-11, 4.18 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Mariners as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Angels vs. Mariners predictions page.

Mariners vs. Angels prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the outcome of Friday's MLB game between the Angels and Mariners 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Mariners a 61% chance of defeating the Angels.

According to our model, the Angels (+1.5) have a 57% chance of covering the run line, while the 7.5-run over/under has a 54% chance of going over.

Angels vs. Mariners odds [9/12/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	Mariners
Run Line	+1.5 (-134)	-1.5 (+115)
Moneyline	+155	-184
Total	o7.5 (+100)	u7.5 (-114)

All odds are correct at the time of publication and are subject to change.

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Angels vs. Mariners picks and best bets

Our model's strongest edge in today's Angels vs. Mariners matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Angels vs. Mariners game-day updates and essential details

Friday's MLB action between the Mariners and Angels at T-Mobile Park is scheduled to commence at 10:10PM ET.

• Who: Los Angeles Angels vs. Seattle Mariners
• Date: Friday, September 12, 2025
• Time: 10:10PM ET/7:10PM PT
• Venue: T-Mobile Park

Dimers' in-depth preview of Friday's Angels vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Angels vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Mariners, with a 61% win probability, will likely beat the Angels on Friday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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