Angels vs. Padres Prediction: San Diego Predicted to Win Wednesday's MLB Matchup [5/14/2025]

MLB action continues on Wednesday at 9:40PM ET as the Los Angeles Angels square off with the San Diego Padres at PETCO Park.

The Padres will have Randy Vásquez (2-3, 3.76 ERA) as their starting pitcher, pitting him against Kyle Hendricks (1-4, 5.30 ERA) for the Angels.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's LA Angels-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 63%, with the Angels at 37%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Angels vs. Padres predictions page.

Padres vs. Angels Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Angels and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 63% chance of beating the Angels.

According to our model, the Angels (+1.5) have a 56% chance of covering the run line, while the 9-run over/under has a 52% chance of staying under.

Angels vs. Padres Odds [5/14/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	Padres
Run Line	+1.5 (-128)	-1.5 (+110)
Moneyline	+158	-185
Total	o9 (-102)	u9 (-118)

All odds are correct at the time of publication and are subject to change.

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Angels vs. Padres Picks and Best Bets

Our model's strongest edge in today's Angels vs. Padres matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Angels vs. Padres Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Padres and Angels at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: Los Angeles Angels vs. San Diego Padres
• Date: Wednesday, May 14, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's full preview of Wednesday's Angels vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any LA Angels vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Padres, with a 63% win probability, will likely beat the Angels on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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