Angels vs. Padres Prediction: San Diego Predicted to Win Wednesday's MLB Matchup [5/14/2025]

The San Diego Padres will square off with the Los Angeles Angels in MLB action at PETCO Park on Wednesday, commencing at 9:40PM ET.

Randy Vásquez (2-3, 3.76 ERA) will be on the bump for the Padres, pitting him against Kyle Hendricks (1-4, 5.30 ERA) for the Angels.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's LA Angels-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 63%, with the Angels at 37%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Angels vs. Padres predictions page.

Padres vs. Angels Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Angels and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Padres a 63% chance of beating the Angels.

According to our model, the Angels (+1.5) have a 55% chance of covering the run line, while the over/under total of 9 runs has a 52% chance of staying under.

Angels vs. Padres Odds [5/14/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	Padres
Run Line	+1.5 (-128)	-1.5 (+110)
Moneyline	+160	-180
Total	o9 (-102)	u9 (-118)

All odds are correct at the time of publication and are subject to change.

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Angels vs. Padres Picks and Best Bets

Our model's biggest edge in today's Angels vs. Padres matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Angels vs. Padres Game-Day Updates and Essential Details

Wednesday's MLB game between the Padres and Angels at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: Los Angeles Angels vs. San Diego Padres
• Date: Wednesday, May 14, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Wednesday's Angels vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any LA Angels vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Padres, with a 63% win probability, will likely beat the Angels on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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