Angels vs. Padres Prediction: San Diego Predicted to Win Monday's MLB Matchup [5/12/2025]

The San Diego Padres and Los Angeles Angels will lock horns in MLB action at PETCO Park on Monday, starting at 9:40PM ET.

Michael King (4-1, 2.22 ERA) will start on the mound for the Padres, pitting him against Yusei Kikuchi (0-4, 3.83 ERA) for the Angels.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's LA Angels-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Padres are likely to win, with a probability of 66%, compared to the Angels' 34%."

For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Angels vs. Padres predictions page.

Padres vs. Angels Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Monday's MLB game between the Angels and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Padres a 66% chance of defeating the Angels.

According to our model, the Angels (+1.5) have a 54% chance of covering the run line, while the over/under total of 7 runs has a 51% chance of going over.

Angels vs. Padres Odds [5/12/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	Padres
Run Line	+1.5 (-110)	-1.5 (-102)
Moneyline	+195	-215
Total	o7 (+100)	u7 (-120)

All odds are correct at the time of publication and are subject to change.

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Angels vs. Padres Picks and Best Bets

Our model's biggest edge in today's Angels vs. Padres matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Angels vs. Padres Game-Day Updates and Essential Details

Monday's MLB game between the Padres and Angels at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: Los Angeles Angels vs. San Diego Padres
• Date: Monday, May 12, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's comprehensive preview of Monday's Angels vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any LA Angels vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Padres, with a 66% win probability, will likely beat the Angels on Monday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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