Angels vs. Brewers prediction: Why Milwaukee is favored to win Wednesday's MLB matchup [9/17/2025]

The Milwaukee Brewers will square off with the Los Angeles Angels in MLB action at American Family Field on Wednesday, beginning at 7:40PM ET.

Brandon Woodruff (6-2, 3.32 ERA) will start for the Brewers, pitting him against José Soriano (10-10, 4.13 ERA) for the Angels.

Based on the latest simulations, Dimers' proven MLB model predicts the Brewers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Angels-Brewers game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Brewers' chance of winning at 64%, with the Angels at 36%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Angels vs. Brewers predictions page.

Brewers vs. Angels prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Angels and Brewers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Brewers a 64% chance of beating the Angels.

According to our model, the Angels (+1.5) have a 55% chance of covering the run line, while the over/under total of 7.5 runs has a 52% chance of going over.

Angels vs. Brewers odds [9/17/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	Brewers
Run Line	+1.5 (-103)	-1.5 (-110)
Moneyline	+194	-210
Total	o7.5 (-112)	u7.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Angels vs. Brewers picks and best bets

Our model's strongest edge in today's Angels vs. Brewers matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

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Angels vs. Brewers game-day updates and essential details

Wednesday's MLB action between the Brewers and Angels at American Family Field is scheduled to commence at 7:40PM ET.

• Who: Los Angeles Angels vs. Milwaukee Brewers
• Date: Wednesday, September 17, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: American Family Field

Dimers' comprehensive preview of Wednesday's Angels vs. Brewers matchup includes our prediction, picks and the latest betting odds.

Before making any Angels vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Brewers, with a 64% win probability, will likely beat the Angels on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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