Angels vs. Astros Prediction: Houston Predicted to Win Saturday's MLB Matchup [4/12/2025]

The Houston Astros and Los Angeles Angels will lock horns in MLB action at Daikin Park on Saturday, starting at 7:10PM ET.

Ryan Gusto (1-0, 1.12 ERA) will start on the mound for the Astros, while the Angels will counter with Tyler Anderson (0-0, 4.50 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Astros as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's LA Angels-Houston game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Astros are more likely to win, while the Angels have a lower chance of victory."

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Angels vs. Astros predictions page.

Angels vs. Angels Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the outcome of Saturday's MLB game between the Angels and Astros 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Astros a 58% chance of beating the Angels.

According to our model, the Angels (+1.5) have a 60% chance of covering the run line, while the over/under total of 9 runs has an equal 50-50 chance of hitting.

Angels vs. Astros Odds [4/12/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	Astros
Run Line	+1.5 (-145)	-1.5 (+125)
Moneyline	+140	-164
Total	o9 (+100)	u9 (-120)

All odds are correct at the time of publication and are subject to change.

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Angels vs. Astros Picks and Best Bets

Our model's biggest edge in today's Angels vs. Astros matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Angels vs. Astros Game-Day Updates and Essential Details

Saturday's MLB game between the Astros and Angels at Daikin Park is scheduled to commence at 7:10PM ET.

• Who: Los Angeles Angels vs. Houston Astros
• Date: Saturday, April 12, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Daikin Park

Dimers.com's comprehensive preview of Saturday's Angels vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any LA Angels vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 58% win probability, will likely beat the Angels on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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