Angels vs. Rockies prediction: Why Colorado is favored to win Sunday's MLB matchup [9/21/2025]

MLB action continues on Sunday at 3:10PM ET as the Los Angeles Angels lock horns with the Colorado Rockies at Coors Field.

The Rockies will start Kyle Freeland (4-16, 5.14 ERA), up against Caden Dana (0-2, 7.45 ERA) for the Angels.

Based on updated simulations, Dimers' advanced MLB model projects the Rockies as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Angels-Rockies game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Rockies with a win probability of 51%, while the Angels have 49%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Angels vs. Rockies predictions page.

Rockies vs. Angels prediction: Who will win?

Using powerful machine learning and data, we have simulated the outcome of Sunday's MLB game between the Angels and Rockies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Rockies a 51% chance of beating the Angels.

According to our model, the 11.5-run over/under has a 52% chance of going over.

Angels vs. Rockies odds [9/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	Rockies
Moneyline	-104	-110
Total	o11.5 (+100)	u11.5 (-118)

All odds are correct at the time of publication and are subject to change.

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Angels vs. Rockies picks and best bets

Our model's strongest edge in today's Angels vs. Rockies matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Angels vs. Rockies game-day updates and essential details

Sunday's MLB game between the Rockies and Angels at Coors Field is scheduled to start at 3:10PM ET.

• Who: Los Angeles Angels vs. Colorado Rockies
• Date: Sunday, September 21, 2025
• Time: 3:10PM ET/12:10PM PT
• Venue: Coors Field

Dimers' in-depth preview of Sunday's Angels vs. Rockies matchup includes our prediction, picks and the latest betting odds.

Before making any Angels vs. Rockies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Rockies, with a 51% win probability, will likely beat the Angels on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Rockies insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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