Angels vs. Rockies prediction: Why Colorado is favored to win Saturday's MLB matchup [9/20/2025]

The Colorado Rockies and Los Angeles Angels will meet in MLB action at Coors Field on Saturday, starting at 8:10PM ET.

The Rockies will send Germán Márquez (3-14, 6.73 ERA) to the mound, pitting him against Kyle Hendricks (7-10, 5.01 ERA) for the Angels.

Based on updated simulation results, Dimers' proven MLB model predicts the Rockies as the most likely winner of today's game.

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Angels vs. Rockies predictions page.

Rockies vs. Angels prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Angels and Rockies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Rockies a 51% chance of beating the Angels.

According to our model, the Rockies (+1.5) have a 60% chance of covering the run line, while the over/under total of 11.5 runs has a 53% chance of going over.

Angels vs. Rockies odds [9/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	Rockies
Run Line	-1.5 (+118)	+1.5 (-140)
Moneyline	-124	+109
Total	o11.5 (-105)	u11.5 (-104)

All odds are correct at the time of publication and are subject to change.

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Angels vs. Rockies picks and best bets

Our model's strongest edge in today's Angels vs. Rockies matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Angels vs. Rockies game-day updates and essential details

Saturday's MLB game between the Rockies and Angels at Coors Field is scheduled to begin at 8:10PM ET.

• Who: Los Angeles Angels vs. Colorado Rockies
• Date: Saturday, September 20, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Coors Field

Dimers' full preview of Saturday's Angels vs. Rockies matchup includes our prediction, picks and the latest betting odds.

Before making any Angels vs. Rockies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Rockies, with a 51% win probability, will likely beat the Angels on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Rockies insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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