Angels vs. Guardians Prediction: Cleveland Predicted to Win Saturday's MLB Matchup [5/31/2025]

The Cleveland Guardians will square off with the Los Angeles Angels in MLB action at Progressive Field on Saturday, commencing at 4:10PM ET.

Slade Cecconi (1-1, 3.27 ERA) will be the starting pitcher for the Guardians, while the Angels will counter with Kyle Hendricks (2-6, 5.23 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Guardians as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's LA Angels-Cleveland game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Guardians are more likely to win, while the Angels have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Angels vs. Guardians predictions page.

Guardians vs. Angels Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Saturday's MLB game between the Angels and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Guardians a 59% chance of defeating the Angels.

According to our model, the Angels (+1.5) have a 60% chance of covering the run line, while the 8-run over/under has a 53% chance of going over.

Angels vs. Guardians Odds [5/31/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	Guardians
Run Line	+1.5 (-140)	-1.5 (+124)
Moneyline	+145	-168
Total	o8 (-108)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

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Angels vs. Guardians Picks and Best Bets

Our model's strongest edge in today's Angels vs. Guardians matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Angels vs. Guardians Game-Day Updates and Essential Details

Saturday's MLB game between the Guardians and Angels at Progressive Field is scheduled to start at 4:10PM ET.

• Who: Los Angeles Angels vs. Cleveland Guardians
• Date: Saturday, May 31, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Progressive Field

Dimers.com's in-depth preview of Saturday's Angels vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any LA Angels vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 59% win probability, will likely beat the Angels on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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