Angels vs. White Sox Prediction: Angels Predicted to Win MLB Opening Day Matchup [3/27/2025]

The Chicago White Sox will square off with the Los Angeles Angels on Opening Day of the 2022 MLB season at Rate Field on Thursday, commencing at 4:10PM ET.

The White Sox will send Sean Burke (0-0, 0.00 ERA) to the mound, while the Angels have opted for Yusei Kikuchi (0-0, 0.00 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Angels as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's LA Angels-CHI White Sox game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Angels with a win probability of 56% and the White Sox with 44%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Angels vs. White Sox predictions page.

EXCLUSIVE OFFER: Sign up to Dimers Pro with code MARCH today to enjoy a full month for the price of just one week!

Angels vs. Angels Prediction: Who Will Win on MLB Opening Day?

Using trusted machine learning and data, we have simulated the result of Thursday's MLB matchup between the Angels and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Angels a 56% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 57% chance of covering the run line, while the over/under total of 7.5 runs has a 52% chance of going over.

Angels vs. White Sox Odds [3/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	White Sox
Run Line	-1.5 (+105)	+1.5 (-120)
Moneyline	-160	+138
Total	o7.5 (-115)	u7.5 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Angels vs. White Sox Picks and Best Bets

Our model's biggest edge in today's Angels vs. White Sox matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Angels vs. White Sox Game-Day Updates and Essential Details

Thursday's MLB action between the White Sox and Angels at Rate Field is scheduled to begin at 4:10PM ET.

• Who: Los Angeles Angels vs. Chicago White Sox
• Date: Thursday, March 27, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Rate Field

Dimers.com's comprehensive preview of Thursday's Angels vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any LA Angels vs. CHI White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Angels, with a 56% win probability, will likely beat the White Sox on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest projections for the World Series, American League, National League and each division.