Angels vs. Red Sox Prediction: Boston Predicted to Win Wednesday's MLB Matchup [6/4/2025]

The Boston Red Sox and Los Angeles Angels will lock horns in MLB action at Fenway Park on Wednesday, starting at 1:35PM ET.

Lucas Giolito (1-1, 4.78 ERA) will start for the Red Sox, pitting him against José Soriano (4-5, 3.41 ERA) for the Angels.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Red Sox as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's LA Angels-Boston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Red Sox' chance of winning at 54%, with the Angels at 46%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Angels vs. Red Sox predictions page.

Red Sox vs. Angels Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Angels and Red Sox 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Red Sox a 54% chance of beating the Angels.

According to our model, the Angels (+1.5) have a 63% chance of covering the run line, while the over/under total of 10.5 runs has a 54% chance of staying under.

Angels vs. Red Sox Odds [6/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Angels	Red Sox
Run Line	+1.5 (-170)	-1.5 (+145)
Moneyline	+116	-134
Total	o10.5 (-105)	u10.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Angels vs. Red Sox Picks and Best Bets

Our model's biggest edge in today's Angels vs. Red Sox matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Angels vs. Red Sox Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Red Sox and Angels at Fenway Park is scheduled to commence at 1:35PM ET.

• Who: Los Angeles Angels vs. Boston Red Sox
• Date: Wednesday, June 4, 2025
• Time: 1:35PM ET/10:35AM PT
• Venue: Fenway Park

Dimers.com's comprehensive preview of Wednesday's Angels vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any LA Angels vs. Boston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Red Sox, with a 54% win probability, will likely beat the Angels on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Angels vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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