Lorenzo Musetti vs. Flavio Cobolli prediction, odds, picks for US Open 2025

Lorenzo Musetti and Flavio Cobolli will lock horns in the third round of the US Open 2025 on Saturday.

Based on the latest simulations, Dimers' advanced tennis model predicts Lorenzo Musetti as the most likely winner of the match.

For expanded analysis of Saturday's match, including best bets and picks, visit our interactive Musetti vs. Cobolli predictions page.

Musetti vs. Cobolli prediction: Who will win and advance to the Round of 16?

Using innovative machine learning and data analysis, we have simulated the outcome of Saturday's Musetti-Cobolli men's singles match 10,000 times as part of our tennis predictions coverage.

Our independent predictive model gives Musetti a 73% chance of beating Cobolli in the US Open 2025.

Additionally, Musetti has a 68% chance of winning the first set, while the under 37.5 games has a 53% chance of hitting, according to our model.

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Lorenzo Musetti vs. Flavio Cobolli odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Musetti	Cobolli
Moneyline	-275	+235
First Set	-200	+162
Total Games	o37.5 (-118)	u37.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Musetti vs. Cobolli picks and best bets

Our model's strongest edge in today's Musetti vs. Cobolli match is on the first set.

Our expert predictions, matched against the current odds, reveal the best tennis picks and tennis best bets for every tournament throughout the year.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Musetti vs. Cobolli updates and essential details

The US Open 2025 match between Lorenzo Musetti and Flavio Cobolli is scheduled to commence on Saturday at 11:00AM ET.

• Who: Lorenzo Musetti vs. Flavio Cobolli
• Date: Saturday, August 30, 2025
• Approx. Time: 11:00AM ET/8:00AM PT
• Tournament: US Open Men's Singles 2025
• Round: Third round

All dates and times in this article are United States Eastern Time unless otherwise noted.

Dimers.com's full preview of Saturday's Musetti vs. Cobolli match includes our prediction, picks and the latest betting odds.

Before making any Lorenzo Musetti vs. Flavio Cobolli picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key tennis betting guides and insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
• Stay informed with guides on where online sports betting is currently legal and which states could legalize next
• Improve your chances with proven sports betting strategies that apply to tennis and more

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Conclusion

We predict Lorenzo Musetti, with a 73% win probability, will likely beat Flavio Cobolli at the US Open 2025.

AI and automation have enhanced this article to quickly deliver accurate Musetti vs. Cobolli insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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