Liberty vs. Old Dominion prediction: Old Dominion favored to win in college football Week 5, 2025

Old Dominion and Liberty will clash in Week 5 college football action at Kornblau Field at S.B. Ballard Stadium on Saturday, starting at 6:00PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts Old Dominion as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Liberty vs. Old Dominion predictions page.

Liberty vs. Old Dominion prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the result of Liberty vs. Old Dominion 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Old Dominion an 83% chance of defeating Liberty. Our predicted final score has Old Dominion winning 34-19.

According to our model, the bookmakers have got it right, and Liberty and Old Dominion each have a 50% chance of covering the spread, while the 53.5-point over/under also has an equal 50-50 chance of hitting.

Liberty vs. Old Dominion odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Liberty	Old Dominion
Spread	+14.5 (-110)	-14.5 (-108)
Moneyline	+470	-625
Total	o53.5 (-112)	u53.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Liberty vs. Old Dominion picks and best bets

Our model's biggest edge in today's Liberty vs. Old Dominion matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Liberty vs. Old Dominion game-day updates and essential details

Saturday's college football action between Old Dominion and Liberty at Kornblau Field at S.B. Ballard Stadium is scheduled to begin at 6:00PM ET.

• Who: Liberty vs. Old Dominion
• Date: Saturday, September 27, 2025
• Time: 6:00PM ET/3:00PM PT
• Venue: Kornblau Field at S.B. Ballard Stadium

Dimers' full preview of Saturday's Liberty vs. Old Dominion matchup includes our prediction, picks and the latest betting odds.

Before making any Liberty vs. Old Dominion picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Old Dominion, with an 83% win probability, will likely beat Liberty on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Liberty vs. Old Dominion insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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