Lehigh vs. Duquesne prediction: Lehigh favored to win in college football Week 3, 2025

Duquesne will take on the favored Lehigh in Week 3 college football action at Arthur J. Rooney Athletic Field on Saturday, commencing at 12:00PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Lehigh as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Lehigh vs. Duquesne predictions page.

Lehigh vs. Duquesne prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the outcome of Lehigh vs. Duquesne 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Lehigh a 71% chance of beating Duquesne. Our predicted final score has Lehigh winning 27-20.

According to our model, the bookmakers have got it right, and Lehigh and Duquesne each have a 50% chance of covering the spread, while the 46.5-point over/under has a 56% chance of staying under.

Lehigh vs. Duquesne odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Lehigh	Duquesne
Spread	-7.5 (-110)	+7.5 (-110)
Moneyline	-290	+240
Total	o46.5 (-110)	u46.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Lehigh vs. Duquesne picks and best bets

Our model's strongest edge in today's Lehigh vs. Duquesne matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Lehigh vs. Duquesne game-day updates and essential details

Saturday's college football matchup between Duquesne and Lehigh at Arthur J. Rooney Athletic Field is scheduled to begin at 12:00PM ET.

• Who: Lehigh vs. Duquesne
• Date: Saturday, September 13, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Arthur J. Rooney Athletic Field

Dimers' in-depth preview of Saturday's Lehigh vs. Duquesne matchup includes our prediction, picks and the latest betting odds.

Before making any Lehigh vs. Duquesne picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for Maryland sports fans

To make the most of Saturday's big day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that scores you $300 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Lehigh, with a 71% win probability, will likely beat Duquesne on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Lehigh vs. Duquesne insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Keep up with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds provide the latest probabilities for the national title game and major conferences.