Las Vegas Raiders vs. Indianapolis Colts early prediction: Expert picks for NFL Week 5, 2025

The Las Vegas Raiders and Indianapolis Colts will meet in Week 5 of the NFL season at Lucas Oil Stadium on Sunday, October 5, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Colts as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Raiders vs. Colts predictions page.

Las Vegas vs. Indianapolis early predictions

Leveraging trusted machine learning and analysis, we have simulated the Raiders vs. Colts game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Raiders 43%, Colts 57%
• Predicted final score: Raiders 21-22 Colts
• Spread: Raiders (+1.5) 50%, Colts (-1.5) 50%
• Total points (44.5): Over 50%, Under 50%

As of September 28, 2025, these Raiders-Colts figures and predictions reflect the latest data and insights available.

Raiders vs. Colts Week 5 details

The NFL Week 5 action between the Colts and Raiders at Lucas Oil Stadium is scheduled for October 5, 2025.

• Who: Las Vegas Raiders vs. Indianapolis Colts
• Date: Sunday, October 5, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Lucas Oil Stadium

Raiders vs. Colts opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: Raiders +1.5 (-110), Colts -1.5 (-110)
• Moneyline: Raiders +105, Colts -125
• Total: Over/Under 44.5 (-112/-108)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Colts, with a 57% win probability, will likely beat the Raiders in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Raiders vs. Colts game, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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