Kentucky vs. South Carolina prediction: South Carolina favored to win in college football Week 5, 2025

South Carolina and Kentucky will lock horns in Week 5 college football action at Williams-Brice Stadium on Saturday, starting at 7:45PM ET.

Based on updated simulations, Dimers' advanced college football model predicts South Carolina as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Kentucky vs. South Carolina predictions page.

Kentucky vs. South Carolina prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the result of Kentucky vs. South Carolina 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives South Carolina a 63% chance of defeating Kentucky. Our predicted final score has South Carolina winning 26-22.

According to our model, Kentucky (+6.5) has a 54% chance of covering the spread, while the over/under total of 47.5 points has a 53% chance of staying under.

Kentucky vs. South Carolina odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Kentucky	South Carolina
Spread	+6.5 (-125)	-6.5 (-105)
Moneyline	+180	-154
Total	o47.5 (-105)	u47.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Kentucky vs. South Carolina picks and best bets

Our model's strongest edge in today's Kentucky vs. South Carolina matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Kentucky vs. South Carolina game-day updates and essential details

Saturday's college football matchup between South Carolina and Kentucky at Williams-Brice Stadium is scheduled to begin at 7:45PM ET.

• Who: Kentucky vs. South Carolina
• Date: Saturday, September 27, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Williams-Brice Stadium

Dimers' full preview of Saturday's Kentucky vs. South Carolina matchup includes our prediction, picks and the latest betting odds.

Before making any Kentucky vs. South Carolina picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict South Carolina, with a 63% win probability, will likely beat Kentucky on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Kentucky vs. South Carolina insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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