Royals vs. Cardinals Prediction: St. Louis Predicted to Win Tuesday's MLB Matchup [6/3/2025]

The St. Louis Cardinals and Kansas City Royals will lock horns in MLB action at Busch Stadium on Tuesday, starting at 7:45PM ET.

Andre Pallante (4-3, 4.23 ERA) will get the ball for the Cardinals, while the Royals will counter with Michael Lorenzen (3-6, 4.33 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Kansas City-St. Louis game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Cardinals with a win probability of 57%, compared to 43% for the Royals."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Royals vs. Cardinals predictions page.

Cardinals vs. Royals Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Royals and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cardinals a 57% chance of defeating the Royals.

According to our model, the Royals (+1.5) have a 62% chance of covering the run line, while the over/under total of 9 runs has a 53% chance of staying under.

Royals vs. Cardinals Odds [6/3/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Cardinals
Run Line	+1.5 (-160)	-1.5 (+140)
Moneyline	+130	-145
Total	o9 (-106)	u9 (-110)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Royals vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Royals vs. Cardinals Game-Day Updates and Essential Details

Tuesday's MLB game between the Cardinals and Royals at Busch Stadium is scheduled to begin at 7:45PM ET.

• Who: Kansas City Royals vs. St. Louis Cardinals
• Date: Tuesday, June 3, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's full preview of Tuesday's Royals vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Kansas City vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cardinals, with a 57% win probability, will likely beat the Royals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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