Royals vs. Cardinals Prediction: St. Louis Predicted to Win Thursday's MLB Matchup [6/5/2025]

MLB action continues on Thursday at 7:45PM ET as the Kansas City Royals take on the St. Louis Cardinals at Busch Stadium.

Matthew Liberatore (3-4, 3.08 ERA) will be on the bump for the Cardinals, while the Royals will counter with Cole Ragans (2-3, 4.53 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Kansas City-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Cardinals with a win probability of 51% and the Royals with 49%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Royals vs. Cardinals predictions page.

Cardinals vs. Royals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Thursday's MLB matchup between the Royals and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cardinals a 51% chance of defeating the Royals.

According to our model, the Cardinals (+1.5) have a 54% chance of covering the run line, while the 7-run over/under has a 53% chance of going over.

Royals vs. Cardinals Odds [6/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Cardinals
Run Line	-1.5 (+175)	+1.5 (-205)
Moneyline	+100	-118
Total	o7 (-115)	u7 (-102)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Royals vs. Cardinals matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

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Royals vs. Cardinals Game-Day Updates and Essential Details

Thursday's MLB matchup between the Cardinals and Royals at Busch Stadium is scheduled to start at 7:45PM ET.

• Who: Kansas City Royals vs. St. Louis Cardinals
• Date: Thursday, June 5, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Thursday's Royals vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Kansas City vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 51% win probability, will likely beat the Royals on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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