Royals vs. Giants Prediction: San Francisco Predicted to Win Wednesday's MLB Matchup [5/21/2025]

MLB action continues on Wednesday at 3:45PM ET as the Kansas City Royals lock horns with the San Francisco Giants at Oracle Park.

The Giants will send Logan Webb (5-3, 2.42 ERA) to the mound, pitting him against Daniel Lynch (3-0, 1.29 ERA) for the Royals.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Giants as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Kansas City-San Francisco game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Giants' chance of winning at 63%, with the Royals at 37%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Royals vs. Giants predictions page.

Giants vs. Royals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Royals and Giants 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Giants a 63% chance of beating the Royals.

According to our model, the Royals (+1.5) have a 57% chance of covering the run line, while the 7.5-run over/under has a 51% chance of staying under.

Royals vs. Giants Odds [5/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Giants
Run Line	+1.5 (-125)	-1.5 (+105)
Moneyline	+185	-220
Total	o7.5 (+102)	u7.5 (-120)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Royals vs. Giants Picks and Best Bets

Our model's strongest edge in today's Royals vs. Giants matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Royals vs. Giants Game-Day Updates and Essential Details

Wednesday's MLB game between the Giants and Royals at Oracle Park is scheduled to start at 3:45PM ET.

• Who: Kansas City Royals vs. San Francisco Giants
• Date: Wednesday, May 21, 2025
• Time: 3:45PM ET/12:45PM PT
• Venue: Oracle Park

Dimers.com's comprehensive preview of Wednesday's Royals vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Kansas City vs. San Francisco picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Giants, with a 63% win probability, will likely beat the Royals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date projections for the World Series, American League, National League and each division.