Royals vs. Padres Prediction: San Diego Predicted to Win Sunday's MLB Matchup [6/22/2025]

The San Diego Padres will take on the Kansas City Royals, in what is expected to be a close MLB game, at PETCO Park on Sunday, beginning at 4:10PM ET.

The Padres will start Randy Vásquez (3-4, 3.70 ERA), pitting him against Seth Lugo (4-5, 3.05 ERA) for the Royals.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Royals-Padres game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Padres with a win probability of 53%, while the Royals have 47%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Royals vs. Padres predictions page.

Padres vs. Royals Prediction: Who Will Win?

Using powerful machine learning and data, we have simulated the outcome of Sunday's MLB game between the Royals and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Padres a 53% chance of defeating the Royals.

According to our model, the 8.5-run over/under has a 53% chance of going over.

Royals vs. Padres Odds [6/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Royals	Padres
Moneyline	+104	-120
Total	o8.5 (-112)	u8.5 (-104)

All odds are correct at the time of publication and are subject to change.

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Royals vs. Padres Picks and Best Bets

Our model's biggest edge in today's Royals vs. Padres matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Royals vs. Padres Game-Day Updates and Essential Details

Sunday's MLB game between the Padres and Royals at PETCO Park is scheduled to start at 4:10PM ET.

• Who: Kansas City Royals vs. San Diego Padres
• Date: Sunday, June 22, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Sunday's Royals vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Royals vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 53% win probability, will likely beat the Royals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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